Plague Rune Pack

Includes:

1 Cham
1 Shael
1 Um

20% Chance to cast level 12 Lower Resist when struck
25% Chance to cast level 15 Poison Nova on striking
Level 13-17 Cleansing Aura When Equipped (varies)
+1-2 All Skills
+20% Increased Attack Speed
+220-320% Enhanced Damage (varies)
-23% To Enemy Poison Resistance
0.3% (0-29.7) Deadly Strike (Based on Character Level)
+25% Chance of Open Wounds
Freezes Target +3

Required Level: 67

Plague is the rune word 'ChamShaelUm' for swords, daggers and katars in Diablo II: Resurrected.

Enemy Poison Resistance and Lower Resist affixes, which boost poison damage, make this runeword a preferred choice for poison-based builds (but not for all). Rabies druids and Martial Arts assassins will utilize it well. For the latter, it helps by lowering all elemental resistances, not only poison. Poison javazon cannot use Plague, as is cannot be created in javelins. Necromancers have a better option and can cast Lower Resist themselves at higher skill level. Plague can be an option if using Poison Dagger, though. Lower Resist proc makes it ideal for other elemental builds. Casters themselves have better weapons, but Act III and Act V hirelings can use it for support.